Cause of Fetal Alcohol Syndrome Fetal alcohol effects is certainly a softer diagnosis than FAS. The diagnosis of possible FAE is considered when the individual has some signs of FAS, the person does not meet all the necessary criteria for FAS, and there is a history of alcohol publicity before birth. As time passes, FAS children generally have eye, ear, and dental problems. Myopia may develop. Issues with the eustachian tube leading to the center ear established the stage for ear infections. There is regular malocclusion and malalignment of one’s teeth. Children with FAS have sufficient difficulty in existence without the additional burden of not being able to see, listen to, and eat normally. These deficits ought to be treated appropriately.Alnylam expects to full this trial in mid-2013. Presented Pre-clinical Data with ALN-TTRsc, a Subcutaneously Delivered RNAi Therapeutic for the Treatment of ATTR. Data offered at the XX International Roundtable on Nucleosides, Nucleotides and Nucleic Acids held August 5-9, 2012 in Montreal, Canada, showed potent, dose-dependent, and durable knockdown of serum TTR with Alnylam's GalNAc-conjugate approach in its ALN-TTRsc pre-clinical program. In nonhuman primates, ALN-TTRsc was administered in a loading regimen of once a complete day for five days, followed by a maintenance regimen of once a week for four weeks leading to an approximately 80 percent reduced amount of TTR at doses as low as 2.5 mg/kg. In addition, in single dose and multi-dose pre-clinical protection studies in rodents and non-human primates, ALN-TTRsc was discovered to be generally safe and well tolerated with a ‘no adverse impact level’ higher than or add up to 300 mg/kg and a therapeutic index exceeding 100 fold, including the absence of any injection site reactions or elevations in pro-inflammatory markers.