This is known as the Warburg Impact. While metabolic changes are an important feature in the transformation of normal cells into cancers cells they aren’t now thought to be cancer's primary cause. Not surprisingly, metabolic adjustments remain an attractive focus on for cancer therapy, today in Open Biology as Krainer and colleagues display in a paper published online, the open-gain access to journal of Great Britain's Royal Society. One difference between fat burning capacity in cancer and regular cells is the switch in tumor to the creation of a different version, or isoform, of a protein created from the pyruvate kinase-M gene.This study began in 2002 in the Lung Toxicology and Biology Laboratory at the Oklahoma State University. When asked about the potential implications of the scholarly study, Dr. Lin Liu, director of the lab and among the authors of the scholarly study, said, With the availability of major alveolar type I cells and the gene expression profile of the cell type, I believe that even more novel features of type I cells in the lung and new therapeutic targets for pulmonary diseases will be discovered in the near future .
An advance toward using stem cells in ‘regenerative medicine’ With stem cells so fickle and indecisive that they make Shakespeare’s Hamlet pale in comparison, scientists today described an advance in encouraging stem cells to create decisions about their fate.