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Genetic variants in CRTH2 predispose sufferers to the advancement of atopic dermatitis. As a CRTH2 antagonist, OC459 provides demonstrated in pre-clinical research that it suppresses the recruitment and creation of essential cells that mediate an allergic response such as for example Th2 lymphocytes, eosinophils and basophils, leading to reduced disease pathology. It really is anticipated that sufferers with an extremely atopic Th2 dominant type of eczema, who typically possess a more severe type of the disease and so are susceptible to flares, will reap the benefits of treatment with OC459.